President Trump Launches Genesis Mission to Propel Scientific Discovery with AI

On November 24, 2025, President Donald J. Trump signed an Executive Order initiating the "Genesis Mission," a national initiative aimed at accelerating scientific discovery through artificial intelligence (AI). This mission seeks to integrate the computational power of the Department of Energy's (DOE) National Laboratories with extensive federal scientific datasets to create a unified AI platform. The platform is designed to automate experiment design, enhance simulations, and develop predictive models, thereby expediting research and development across various scientific fields. The Executive Order directs the Assistant to the President for Science and Technology to coordinate with key federal agencies, including the National Science Foundation (NSF), National Institute of Standards and Technology (NIST), and National Institutes of Health (NIH), to implement this initiative. The Genesis Mission is envisioned as a comprehensive effort to harness AI for transformative scientific breakthroughs, addressing pressing national challenges.

The Genesis Mission aims to develop an integrated platform that connects the world's best supercomputers, experimental facilities, AI systems, and unique datasets across every major scientific domain to double the productivity and impact of American research and innovation within a decade. The Department of Energy (DOE) is tasked with leading the initiative, leveraging its 17 National Laboratories to build the integrated discovery platform. The Executive Order directs the Assistant to the President for Science and Technology to coordinate with key federal agencies, including the National Science Foundation (NSF), National Institute of Standards and Technology (NIST), and National Institutes of Health (NIH), to implement this initiative.

The Department of Energy (DOE) is a federal agency responsible for overseeing national energy policy and research. The DOE's 17 National Laboratories are at the forefront of scientific research and innovation. These laboratories are instrumental in conducting cutting-edge research across various scientific domains, including energy, materials science, and national security. The Assistant to the President for Science and Technology advises the President on scientific and technological matters and coordinates related federal initiatives.

Michael Kratsios, Assistant to the President for Science and Technology, stated:

"President Trump is taking a revolutionary approach to scientific research, harnessing the power of AI to propel America into the Golden Age of Innovation. The Genesis Mission connects world-class scientific data with the most advanced American AI to unlock breakthroughs in medicine, energy, materials science, and beyond."

Brandon Williams, Administrator of the National Nuclear Security Administration, commented:

"The Genesis Mission represents the next great chapter and an unparalleled opportunity for America’s scientific and national security leadership."

The Executive Order outlines the establishment of the Genesis Mission, detailing the roles of various federal agencies and the objectives of the initiative. The order emphasizes collaboration among federal agencies to align AI-related programs, datasets, and research activities with the mission's objectives.

Prior to the Genesis Mission, the Trump administration prioritized AI development to outpace global competitors like China, aligning with previous decisions to reduce AI regulatory restrictions and repeal former President Biden's AI safety executive order. The Genesis Mission has been likened to the Apollo Program in terms of its scale and ambition, aiming to achieve transformative scientific breakthroughs through coordinated national effort.

By integrating AI with extensive scientific datasets, the Genesis Mission has the potential to accelerate discoveries in fields such as medicine, energy, and materials science. The initiative may stimulate economic growth by fostering innovation and maintaining the United States' competitive edge in AI and scientific research. Enhancing AI capabilities can contribute to national security by improving technologies related to defense and critical infrastructure.

The Genesis Mission represents a significant federal initiative to harness artificial intelligence for accelerating scientific discovery. By integrating the computational power of the Department of Energy's National Laboratories with extensive federal scientific datasets, the mission aims to create a unified AI platform that automates experiment design, enhances simulations, and develops predictive models. This comprehensive effort is poised to address pressing national challenges and position the United States at the forefront of global scientific innovation.