Los Angeles Rams Triumph Over San Francisco 49ers 42-26

In a commanding performance on November 9, 2025, the Los Angeles Rams defeated the San Francisco 49ers 42-26 at Levi's Stadium in Santa Clara, California. Quarterback Matthew Stafford led the charge, throwing four touchdown passes and setting a new NFL record with his third consecutive game of at least four touchdown passes without an interception.

The Rams (7-2) extended their winning streak to four games, maintaining a tie with the Seattle Seahawks atop the NFC West division. This victory also avenged their earlier overtime loss to the 49ers (6-4) in Week 5 of the season.

Game Highlights

Stafford completed 24 of 36 passes for 280 yards, bringing his season total to an NFL-leading 25 touchdown passes. Running back Kyren Williams contributed significantly with 73 rushing yards and two touchdowns on 14 carries. Wide receiver Davante Adams had six receptions for 77 yards and a touchdown before exiting in the fourth quarter due to an oblique injury. Rookie wide receiver Puka Nacua added five receptions for 64 yards, including a 22-yard touchdown catch.

The Rams' offense was efficient, converting 10 of 13 third-down attempts and scoring touchdowns on six of their first eight drives. They established an early lead, scoring touchdowns on their first three possessions to go up 21-0 early in the second quarter.

On the 49ers' side, quarterback Mac Jones completed 33 of 39 passes for 319 yards and three touchdowns. Tight end George Kittle had a standout performance with nine receptions for 84 yards and a touchdown, setting a season-high for receptions.

Injury Report

Adams' oblique injury occurred in the fourth quarter. Coach Sean McVay indicated that Adams could have returned if the game had been closer. Adams' status for upcoming games remains uncertain.

Historical Context

This victory avenged the Rams' earlier overtime loss to the 49ers in Week 5 of the 2025 season. The Rams' current four-game winning streak positions them strongly in the NFC West race.

Implications for Playoff Standings

With this win, the Rams improved to a 7-2 record, maintaining a tie with the Seattle Seahawks atop the NFC West. The 49ers, now at 6-4, will need to regroup as they prepare for their next divisional matchup.

The Rams' offensive resurgence, led by Stafford's record-breaking performances, has been a key factor in their recent success. As the season progresses, maintaining this momentum will be crucial for their playoff aspirations.