Science & Tech

Preprint: Reinforcement-learning controller trained in surrogate flows cuts simulated wing drag in zero-shot tests

A preprint reports an RL controller trained in surrogate channel flows cuts simulated NACA4412 skin-friction ~29% and total drag ~11%; simulation-only, unreviewed.

#ai, #aerodynamics, #turbulence, #reinforcementlearning

SCIENCE

Engineered miniature CRISPR achieves >80% editing in human cells and could fit inside AAV

Engineered miniature CRISPR raised editing in human cells from <10% to >80% and stays small enough to fit in AAV vectors — tests remain in cells.

#gene-editing, #crispr, #aav, #biotechnology

SCIENCE

Engineered "Smart" Nanomaterial Reduces Intracellular MRSA in Mice and Piglets, Study Shows

Lab-made peptide–dendron nanoparticles reshape in response to bacterial enzymes and reduce intracellular MRSA in mice and piglets, a step toward smart antimicrobials.

#nanomedicine, #mrsa, #antibiotics, #ferroptosis

SCIENCE

Study: dual‑target off‑the‑shelf CAR‑T cells resist rejection, curb tumor escape in mice

Nature Communications study finds donor 'off‑the‑shelf' CAR‑T cells targeting CD19 and CD70 persist longer and better control tumors in preclinical models.

$ALLO, #car-t, #immunotherapy, #allogeneic, #cd70

SCIENCE

Engineered ‘living’ cell implant normalizes blood pressure in mice, study shows

Engineered human cell implants sense angiotensin II and secrete soluble ACE2 to restore normal blood pressure in hypertensive mice.

#syntheticbiology, #hypertension, #genetherapy, #ace2

SCIENCE

Pol32 phosphorylation strengthens RPA binding and promotes mutagenic break‑induced replication in yeast

Study in budding yeast finds phosphorylation of two threonines in Pol32 strengthens its binding to RPA and promotes mutagenic break‑induced replication.

#dna-repair, #bir, #pol32, #yeast

SCIENCE

23andMe study finds common gene variants modestly affect weight loss and nausea on GLP‑1 drugs

A Nature paper by 23andMe links common DNA variants to small differences in weight loss and nausea on GLP‑1 drugs; the company released a consumer report.

#genetics, #glp1, #23andme, #weightloss, #semaglutide

SCIENCE

Study projects nearly 2.6 billion people could face frequent ‘hot‑dry’ heat-and-drought extremes by 2090s

A new study finds that under current trajectories about 28% of humanity—nearly 2.6 billion people—could face frequent simultaneous heat and drought by the 2090s.

#climate, #heat, #drought, #adaptation

SCIENCE

NASA Begins Scrutinizing Artemis II’s Lunar Flyby Data as Orion Heads Home

After Artemis II's lunar flyby, NASA is analyzing 50+ GB of images, audio and measurements — including meteoroid flashes and far‑side imagery — as Orion returns.

#space, #nasa, #artemis, #moon

SCIENCE

NIH Spotlights Women's Health and BRAIN Tech Partnerships — No New Funding Announced

NIH's April 7 meetings emphasized maternal health, equity and disseminating BRAIN technologies — but released no new funding or formal policy changes.

#nih, #womenshealth, #braininitiative, #researchfunding

SCIENCE

Glial relay in hypothalamus links blood sugar to appetite suppression

Rodent study reveals a glia‑to‑glia‑to‑neuron circuit: tanycytes release lactate, activating astrocytes that excite appetite‑suppressing POMC neurons.

#neuroscience, #appetite, #glia, #hypothalamus

SCIENCE

NOAA‑20 Misses Ground Contact, Causing One‑Orbit Delay in Weather Data

NOAA reports a brief delay in stored mission data from polar satellite NOAA‑20 after an April 6 ground contact miss; engineers expected recovery on a later pass.

#noaa, #weather, #satellites, #satelliteops

SCIENCE