Science & Tech

Intellia’s one-time CRISPR therapy cuts hereditary angioedema attacks 87% in Phase 3; rolling FDA filing started

Phase 3 trial of Intellia's one-time in‑vivo CRISPR therapy lonvo‑z cut hereditary angioedema attacks 87%; company began rolling FDA filing.

$NTLA, #crispr, #geneediting, #biotech, #hereditaryangioedema, #intellia

UK to spend nearly £30m to expand AI diagnostics in the NHS; £20m to roll out chest X‑ray tools to trusts by 2029

UK to invest almost £30m to expand AI-assisted diagnostics in the NHS, including £20m to roll out AI chest X-ray tools to all English trusts by 2029.

#nhs, #ai, #healthcare, #lungcancer

Largest Bundibugyo Ebola Outbreak on Record Reaches 534 Confirmed Cases, Spreads to Uganda

The Bundibugyo ebolavirus outbreak has reached 534 confirmed cases across DRC and Uganda, straining responders where no licensed vaccines or treatments exist.

#ebola, #drc, #uganda, #publichealth, #outbreak

U.S. Measles Cases Top 2,000 by Early June as 2026 Approaches Last Year’s Total

CDC reports 2,030 confirmed measles cases as of June 4, 2026, raising concerns about outbreaks, vaccination gaps and importation risks.

#measles, #vaccination, #cdc, #publichealth

UK Phase I trial finds AI-designed coronavirus vaccine candidate safe and elicits cross-reactive immune responses

Phase I UK trial: an AI-designed DNA vaccine for sarbecoviruses was safe in 39 adults and induced cross-reactive immune responses, but not proof it protects.

#covid-19, #vaccine, #clinicaltrials, #ai

Lancet warns lack of rapid test hampers response to Bundibugyo Ebola in DRC and Uganda

Lancet Comment: no reliable rapid test for Bundibugyo Ebola is delaying isolation, testing and contact tracing during the DRC–Uganda outbreak.

#ebola, #bundibugyo, #diagnostics, #drcongo, #uganda

Pfizer’s BRAFTOVI Combo Shows Longer Progression-Free Survival in First-Line BRAF V600E Metastatic Colorectal Cancer

Phase 3 BREAKWATER Cohort 3 data show encorafenib plus cetuximab with FOLFIRI extended median PFS to 15.2 months vs. 8.3 months in control.

$PFE, #oncology, #colorectalcancer, #pfizer, #braftovi

Interim phase 3: Sacituzumab tirumotecan plus pembrolizumab improves PFS in PD-L1–positive advanced NSCLC

Interim phase 3 data: adding sacituzumab tirumotecan to pembrolizumab improved progression-free survival versus pembrolizumab alone in PD‑L1+ advanced NSCLC; OS immature, toxicity higher.

$MRK, #lungcancer, #pembrolizumab, #sacituzumabtirumotecan, #clinicaltrials

EMA Recommends COVID-19 Vaccines Be Updated to Target XFG for 2026–27 Campaign

EMA’s Emergency Task Force recommends updating COVID-19 vaccines to target the XFG variant for the 2026–2027 season, guiding EU manufacturers and health authorities.

#covid-19, #ema, #vaccines, #xfg

NHS vacancies in England fall slightly to 97,475 by end of March 2026, but tens of thousands remain unfilled

NHS vacancies in England dipped to 97,475 (6.5%) at March 31, 2026, with nursing and medical gaps narrowing — but the figures carry major caveats.

#nhs, #vacancies, #nursing, #doctors, #england

NHS England screening programme detects 10,678 lung cancers, majority found at early stages

NHS England’s lung screening programme has detected 10,678 cancers, with more than three-quarters found at stage 1 or 2 after community mobile scans.

#lungcancer, #nhs, #screening, #publichealth

WHO declares PHEIC and Africa CDC issues continental alert for Bundibugyo Ebola in DRC and Uganda

WHO raised its top alert and Africa CDC activated a continental emergency over a Bundibugyo Ebola outbreak affecting eastern DRC and cases in Uganda.

#ebola, #publichealth, #who, #africa

FDA Approves Hepcludex, First U.S. Treatment for Chronic Hepatitis Delta

The FDA cleared Hepcludex (bulevirtide-gmod) for adults with chronic hepatitis D, the first approved U.S. therapy for this serious liver infection.

#hepatitisd, #fda, #gilead, #antivirals

Johns Hopkins–Lancet Commission Releases Report on Health, Conflict and Forced Displacement at World Health Assembly

A Johns Hopkins–Lancet commission publishes a report on health in conflict and forced displacement, launching in Geneva during the World Health Assembly.

#humanitarian, #health, #conflict, #displacement

WHO declares Ebola outbreak in eastern DR Congo and Uganda a global public health emergency

WHO on May 17 declared the Bundibugyo Ebola outbreak in Ituri Province, DR Congo, with confirmed cases in Uganda, a Public Health Emergency of International Concern.

#ebola, #who, #drcongo, #uganda, #publichealth