Science & Tech

Single IV CRISPR Dose Produces ~50% LDL and Triglyceride Reductions at One Year in Early Trial

A single IV dose of CRISPR Therapeutics’ CTX310 produced about 50% average reductions in LDL cholesterol and triglycerides at one year in a small Phase 1a trial.

$CRSP, #crispr, #lipids, #geneediting, #angptl3

NHS launches pilot of rapid genomic test to cut brain tumour diagnosis from weeks to days

NHS England is piloting a rapid genomic test for brain tumours in five specialist centres, aiming to shorten diagnosis from weeks to days.

#nhs, #genomics, #brain-tumour, #diagnostics, #oncology

NHS-Galleri Trial Misses Primary Endpoint; Secondary Analysis Shows Fewer Stage IV Cancers

A large randomized NHS trial of Grail’s Galleri multi-cancer blood test missed its primary endpoint, though secondary analysis found fewer Stage IV cancers.

#cancer, #screening, #galleri, #clinicaltrials

England dashboard: 1.4 million waiting for mental health care as NHS outlines £21.4bn 2026/27 plans

NHS England’s new quarterly dashboard shows 1.415m people waiting for mental-health care in July and planned mental-health spending of £21.376bn for 2026/27.

#mentalhealth, #nhs, #england, #healthpolicy

Lancet urges compassionate care as central to controlling DRC’s Bundibugyo Ebola outbreak

A Lancet commentary argues that accessible, high-quality supportive care is essential to controlling the DRC’s growing Bundibugyo Ebola outbreak.

#ebola, #drc, #publichealth, #lancet

Durvalumab Plus FLOT Boosts Survival in Resectable Gastric and GEJ Cancer, MATTERHORN Shows

Phase 3 MATTERHORN shows AstraZeneca’s durvalumab added to perioperative FLOT improves overall and event‑free survival in resectable gastric/GEJ cancer.

$AZN, #oncology, #immunotherapy, #durvalumab, #gastric-cancer, #astrazeneca

Gene-edited pig kidney supported a human for 271 days and didn’t block later transplant, case report finds

A Lancet case report shows a gene-edited pig kidney kept a patient off dialysis for 271 days and didn’t impede a later human transplant.

#xenotransplantation, #kidneytransplant, #egenesis, #organtransplant

FDA Approves Zanvastro, First Therapy for Alexander Disease

FDA approves Zanvastro (zilganersen), the first approved therapy for Alexander disease, for patients from infancy through adulthood. Ionis received approval.

$IONS, #health, #fda, #alexanderdisease, #ionis

Sham-controlled trial finds pulmonary vein isolation no better than sham for atrial fibrillation quality of life at six months

A multicentre sham-controlled trial in Europe published in The Lancet found PVI didn’t improve AF-related quality of life versus sham at six months.

#atrialfibrillation, #catheterablation, #cardiology, #clinicaltrials

Phase 1 study: single dose of Kylo-11 sharply lowers Lp(a) for up to 48 weeks

A phase 1 trial in The Lancet found one dose of experimental siRNA Kylo-11 was well tolerated and cut Lp(a) by up to ~98% for months.

#lpa, #cardiology, #drugdevelopment, #sirna

FDA Approves Rasonque (daraxonrasib), First Targeted Therapy for Most Common Form of Metastatic Pancreatic Cancer

FDA cleared Rasonque for adults with previously treated metastatic pancreatic adenocarcinoma after a Phase 3 trial showed a significant overall survival benefit.

$RVMD, #health, #pancreaticcancer, #oncology, #drugapproval

FDA Clears Abbott’s Libre Duo 10 Day, First U.S. Wearable to Continuously Monitor Ketones and Glucose

FDA authorizes Abbott’s Libre Duo 10 Day, the first U.S. wearable to continuously monitor ketones and glucose for ages 2 and up.

#diabetes, #fda, #medicaldevices, #abbott

Study finds at least 24.5% of former NFL players who died 2016–2021 had CTE

Using deaths of 878 former NFL players (2016–2021), researchers estimate at least 24.5% had CTE, with a plausible prevalence range up to 97.7%.

#cte, #nfl, #braininjury, #neuroscience

NHS begins rolling out free at-home HPV self-test kits to nearly 4 million overdue for cervical screening

NHS England is inviting nearly 4 million people overdue for cervical screening to order free at-home HPV self-test kits to boost uptake and prevent cancer.

#nhs, #hpv, #cervicalscreening, #publichealth, #cancer

Statistics Canada links seven CHMS cycles to administrative health records for longitudinal research

Statistics Canada linked seven CHMS cycles (2007–2024) with administrative health records, letting approved researchers study biomarkers and later outcomes.

#statisticscanada, #healthsurvey, #researchdata, #chms